Cagrilinitide 10MG

Cagrilintide is a long-acting acylated amylin analogue designed as a non-selective agonist at amylin receptors (AMYRs) and calcitonin receptors (CTR). It features lipidation for extended half-life and exhibits an amylin-like binding mode with distinct conformational dynamics at calcitonin-family receptors. Structural studies highlight an intramolecular salt bridge (E14-R17) contributing to helical stability and specific residue interactions (such as F23 anchoring) in receptor complexes. It has been investigated in multiple phase 2 and phase 3 trials as a monotherapy and in combination settings for metabolic research models.